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KMID : 1161420100130030725
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Journal of Medicinal Food
2010 Volume.13 No. 3 p.725 ~ p.728
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The Effect of Grape Seed Extracts on Serum Paraoxonase Activities in Streptozotocin-Induced Diabetic Rats
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Kiyici Aysel
Okudan Nilsel
Gokbel Hakki
Belviranli Muaz
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Abstract
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Procyanidins, a group of flavonoids, are oligomeric forms of catechins that are abundant in red wine, grapes, cocoa, and apples. Paraoxonase acts as an antioxidant enzyme and protects low-density lipoprotein-cholesterol against oxidation. In our study we aimed to evaluate the effects of grape seed extract (GSE) on paraoxonase activities in streptozotocin-induced diabetic rats. Our study included four groups of rats: Group I (n?=?8), control; Group II (n?=?10), GSE-supplemented; Group III (n?=?6), streptozotocin-induced diabetic; and Group IV (n?=?7), GSE-supplemented diabetic rats. Serum paraoxonase activities were determined with a spectrophotometric method. Paraoxonase activities in Group III were significantly lower than in the other three groups (P?
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KEYWORD
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diabetes, grape seed extract, paraoxonase
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